It is suspected that perrottetinene is an active cannabinoid agonist but has yet to be proven, it has been.The human body possesses specific binding sites on the surface of many cell types for cannabinoids,and our body produces several endocannabinoids, fatty acid derivatives that bind to thesecannabinoid receptors (CB) and activate them. Marginata is perrottetinenic acid which has a similar molecular structure to Delta(1) tetrahydrocannabinol and was published in 2002, perrottetinene is an already known cannabinoid found in this and other species of Radula, in particular, R. perrottetii is a chemically isolated species in the Radulaceae.The new cannabinoid found in R.
Some prenyl-containing bibenzyls showed 5-lipoxygenase and calmodulin in hibitory activity and vasopressin antagonist activity. complanata are confirmed as correct by difference NOE. The structures of the previously reported radulanins A and H isolated from R. complanata together with 2- and 4-(3-methyl-2-butenyl)-3,5-dihydroxybibenzyls and its structure elucidated by comparison of 1H and 13C NMR spectral data with those of radulanins A and H.
Radulanin L, a new bibenzyl with a dihydrooxepin skeleton was isolated from R.
perrottetii are revised by analysis of their 1H and 13C NMR data, difference NOE experiments and synthesis of their derivatives.
The structures of the previously reported chalcone and three prenyl bibenzyls, perrottetins A, B and C, and the other two bibenzyls, isolated from R. The structures of the new compounds have been characterized as 2( R)-2-isopropenyl-6-hydroxy-4-(2-phenylethyl)dihydrobenzofuran and 2,2-dimethyl-7,8-dihydroxy-5-(2-phenylethyl)chromene by 1H and 13C NMR spectral analysis and synthesis. A new dihydrobenzofuran and a new chromene derivatives have been isolated from the liverwort Radula perrottetii, together with the known 3,5-dihydroxy-2-(3-methyl-2-butenyl)bibenzyl, 2( R)-2-isopropenyl-6,7-dihydroxy-4-(2-phenylethyl)dihydrobenzofuran, 2,2-dimethyl-7-hydroxy-5-(2-phenylethyl)chromene, 3,5-dihydroxy-6-carbo-methoxy-2-(3-methyl-2-butenyl)bibenzyl, three bis(bibenzyls) and perrottetins E, F and G.
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